Clicking on the link redirects unwitting surfers to an online pharmacy service.
Windows Live SkyDrive is an online storage service launched in beta in August. Users can upload and share files with anyone via web links.
This latest spam campaign saw an HTML file uploaded with a redirect to an online pill store.
McAfee estimates that the spammers uploaded "tens of thousands" of such files to the Microsoft service.
"Services like Windows Live SkyDrive are attractive to spammers for a number of reasons," said Chris Barton, lead anti-spam researcher at McAfee Avert Labs.
"These services are free, they provide unique long-lasting web links, they host almost any kind of file and are relatively safe from blacklisting."
Spammers are regularly turning their attention to online services, including storage services and blogs.
McAfee Avert Labs recommends that service providers scan the content placed on their systems to weed out spam and malicious content.
.png&h=140&w=231&c=1&s=0)
.jpg&h=140&w=231&c=1&s=0)
.jpg&w=100&c=1&s=0)
.png&w=100&c=1&s=0)
iTnews State of Security Breakfast Sydney
iTnews Executive Retreat - Security Leaders Edition - VIC
.png&h=140&w=231&c=1&s=0)
.png&h=140&w=231&c=1&s=0)
