Mike Reavey, of Microsoft's Security Response Center, said on a company blog that the problems, so far, appear to be mostly on consumer-level products.
"The scope is limited at the moment, but the impact might be that an application could hang when conducting certain operations, like opening a file from the "File-open dialog in an application," he said.
The patch, MS06-015, was released last week to fix numerous flaws in IE and was called "critical" by Microsoft, meaning a malicious user could execute code onto a PC to take control of a computer.
In a bulletin on its support website, Microsoft said on Saturday that the issue may cause inability to access "My Documents" or "My Pictures" folders, unresponsive Microsoft Office applications, ineffective address bars and other problems.
The issues are caused by Microsoft installing the verclisd.exe file, which stops responding after being identified by HP's Share-to-Web software, according to Microsoft's support website.
The file is also flagged by Sunbelt's Kerio Personal firewall.
Microsoft recommended PC users manually edit the registry to fix the issues.
The Redmond, Wash., software giant released five patches, three of which were called critical, in last week's Patch Tuesday release.
One of the flaws fixed was the infamous createTextRange() flaw in IE, which some security vendors created an unofficial patch for.