Amazon is the latest web giant to suffer a large-scale outage, as its store front home page went offline for three-quarters of an hour overnight Australian time.
Along with the home page, the Kindle store was also inaccessible and people reported problems connecting to Amazon's Web Services as well, as first reported by GigaOm.
Regional Amazon sites and those owned by the web retailing giant, such as Zappos, continued to operate and network connectivity to the main amazon.com site stayed up, chief executive of Cloudflare, Matthew Prince, noted.
Amazon is yet to provide an explanation for the outage, but Prince said it may be due to the application driving the site or an internal network issue.
Both Google and Microsoft experienced service disruptions over the weekend.
Amazon suffered what was described as "the worst outage in cloud computing history" in April 2011, when the AWS Elastic Cloud Compute 2 (EC2) service experienced a catastrophic failure and slow restoration over six days.