DLA Piper said that an estimated £5 of every £100 spent at auction sites goes on counterfeit items.
Products most at risk include fashion and cosmetic items, something online auction giant eBay has become familiar with in recent weeks.
The research also warned that auction sites are a second home for 'grey market' trading, in particular the sale of imported consumer electronics, motor equipment and sports goods at highly inflated prices.
"Counterfeit goods dilute the value of brands, undermine the integrity of auction sites and cost the UK economy millions of pounds in lost income," said Simon Levine, joint global head of DLA Piper's technology, media and commercial group.
"But this is not just about protecting brand owners; it is for the consumer's benefit also.
"If you invest your trust and money in a brand you want to know you're getting the real thing, whether that's make-up and cosmetics or domestic appliances and children's toys."
Responsibility for dealing with this problem does not lie solely with the websites, according to DLA Piper, but must be carried by consumers and copyright owners as well.
James Ramm, director of ComSec International, said: "E-fencing poses a significant threat to brands and is a false economy for buyers.
"We use the very latest software to track the infringement of brands online by scanning image and text descriptions, but our data is still only the tip of the iceberg.
"The full extent of counterfeit trading online may never be known and will continue to thrive unless consumers, brands and the sites in question take action against illegal traders."