The Sims is still a long way behind Nintendo's multiplatform Mario franchise, which has sold 201 million units across all platforms.
However, it is well ahead of other popular franchises such as Halo and Grand Theft Auto.
EA claimed that The Sims' influence extends far beyond the game itself, spawning an online community that racks up 4.3 million unique visitors per month.
"The Sims has been an interactive experience for people around the globe to explore their passion for creativity, and we are thrilled to be a part of that," said Rod Humble, studio head for The Sims label.
Created by Will Wright, founding father of the so-called 'God game' genre, The Sims has proved to be a hit with women, who make up 60 per cent of the game's audience.
EA recently unveiled the first official details of the next version of The Sims, which will launch in 2009.
Nearly three years in the making, The Sims 3 will feature a new games engine that promises greater immersion and "unlimited customisation".
"In The Sims 3, Sims can go beyond the boundaries of their home lot, and immerse themselves in an open, living neighbourhood, interacting with other Sims using our new deeper personality system," said Humble.